Mobilized Peripheral Blood Leukopaks®

mobilized leukopak

Human Mobilized Peripheral Blood Leukopaks® are collected from healthy IRB consented donors that are injected with Granulocyte-Colony Stimulating Factor (G-CSF aka Neupogen®) or a combination of Plerixafor (aka Mozobil®) and G-CSF, which increases circulating leukocytes and stimulates the bone marrow to produce a large number of hematopoietic and progenitor stem cells and mobilizes these cells into the bloodstream, allowing for enriched CD34+ hematopoietic stem cells from a single donor as compared to traditional Leukopaks®. Collecting CD34+ stem cells from a single donor eliminates donor-to-donor variation, allows scalability of stem cell studies, and decreases same cell variability. Mobilized Leukopaks® are ideal for stem cell studies relating to regenerative medicine, immunotherapy, and transplant therapy.

Your Cells, Your Way!

HIGH-QUALITY MOBILIZED LEUKOPAKS

Cell-rich Mobilized Leukopaks are extracted using an FDA-approved apheresis machine. Once collected, Mobilized Leukopaks are sent out on the day of collection to ensure you receive a fresh product.

 

  • 2x10e10 TNCs/full bag
  • Enriched CD34+ cells
  • Highly-enriched PBMCs
  • Low granulocyte
  • Low hematocrit
  • ≥90% viability
  • HBV, HCV, HIV negative
  • IRB approved
Representative flow panel of fresh G-CSF Mobilized Leukopak®
FIGURE 1. Representative flow panel of fresh G-CSF Mobilized Leukopak®. Enriched PBMC population with low granulocytes (20.76%), high viability (97.65%), and a high percentage of CD34+ cells (1.68%).

DONOR SELECTION

  • Extensive donor pool
  • Specific donor demographics (age, weight, ethnicity, etc.)
  • Donor lifestyle characteristics (BMI, smoker/non-smoker, etc.)
  • Medical history (allergies, medications, etc.)
  • HLA, RhD, and ABO typing available
  • Additional infectious disease screening (LCMV, etc.)
  • Much more....

CELL COLLECTION/PROCESSING

  • Special processing procedures available
  • Different mobilization agents available

EXPEDIENCY FROM ORDER TO DELIVERY

  • Custom media/buffer
  • Customizable packaging options
  • Cryo shipping available
  • FedEx®, World Courier®, UPS®
  • Same day delivery in select cities

Popular Mobilized Peripheral Blood Leukopaks®

Frequently Asked Questions

What mobilization agents do you use?

We offer G-CSF, Plerixafor, and G-CSF plus Plerixafor options to mobilize the cells from the bone marrow.

Can I get LCMV testing done on a mobilized Leukopak?

Yes, LCMV testing can be done upon request.

Where can StemExpress ship products?

All over the world. We have a variety of shipping methods to meet your needs. Please inquire for more information.

Why does StemExpress offer different mobilization agents?

StemExpress offers PBMCs and CD34+ stem cells mobilized with G-CSF, Plerixafor, and G-CSF plus plerixafor. The mechanism of action of these mobilization agents, and the combination of them, have been shown to change the expression profile, cell composition, and engraftment potential of the mobilized cells.1,2,3 Therefore, it is important to understand that switching mobilization reagents during a study may also change the mobilized cell type and their effect on studies relating to transplantation and stem cell research.


1. Broxmeyer, et al. (2005) Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med. 201(8):1307–1318.
2. Larochelle, et al. (2006) AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates. Blood. 107(9):3772–3778.
3. Lidonnici, et al. (2017) Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced in vivo homing capacity compared to plerixafor alone. Haematol. 102(4):120-124.

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Call 530.303.3828 or Contact Us